49ERS GAME AT A GLANCE
Opponent: Detroit Lions
Time: 5:20 p.m.
Line: 49ers by 7
Records: 49ers 1-0, Lions 1-0
TV: Ch. 3 (Al Michaels play by play, Cris Collinsworth color)
Radio: 680, 1320
MATCHUP TO WATCH
49ers right guard Alex Boone vs. Lions defensive tackle Ndamukong Suh
Boone had a very good debut at guard against the Packers last week, but he will have to be even better against Suh and Detroit's big and physical front line. The 49ers attacked Suh in the running game in their win in Detroit last year, with Frank Gore rushing for 141 yards and a touchdown. Look for a similar approach this year as the 49ers try to demoralize the Lions' defense early.
THREE KEYS TO GAME
Lions quarterback Matthew Stafford threw three interceptions last week against the Rams, and the 49ers need at least one or two to slow down Detroit's passing attack. NaVorro Bowman's interception last week was a key play in the 49ers' win.
Detroit wide receiver Calvin Johnson (6-foot-5) has a considerable size advantage on the 49ers' defensive backs, especially cornerback Tarell Brown (5-10) and safety Donte Whitner (5-10). The 49ers have to attack the ball when it's on its way to Johnson.
Although it should have been called back on an illegal block, the 49ers gave up a punt-return touchdown last week, something they also did in the preseason. Their coverage units are still congealing and must find a leader.
Questionable: WR Ted Ginn Jr. (ankle), RB Brandon Jacobs (knee)
Probable: LB NaVorro Bowman (shoulder), P Andy Lee (hand)
Out: CB Bill Bentley (concussion)
Doubtful: S Louis Delmas (knee), CB Chris Houston (ankle), LB Travis Lewis (quadriceps)
Questionable: DE Lawrence Jackson (calf), DT Corey Williams (knee)
Probable: WR Calvin Johnson (foot)