The 49ers, who play the Seahawks in Seattle on Sunday night, are 5-0 in prime time this season:
1. 49ers 27, Lions 19 (Sept. 16): Coach Jim Harbaugh refrains from a slap-happy postgame reunion with visiting Detroit coach Jim Schwartz.
2. 49ers 13, Seahawks 6 (Oct. 18): Frank Gore rushes for 131 yards and Alex Smith remember him? throws a touchdown pass to beat visiting Seattle.
3. 49ers 24, Cardinals 3 (Oct. 29): Smith completes 18 of 19 passes for 232 yards as visiting Arizona matches its 4-0 start with its fourth loss in a row.
4. 49ers 32, Bears 7 (Nov. 19): Colin Kaepernick passes for 243 yards and two touchdowns in the biggest coming-out party in the history of, uh, coming-out parties.
5. 49ers 41, Patriots 34 (Sunday): This cold-weather classic could be a Super Bowl preview of next season's game when it's played at MetLife Stadium in East Rutherford, N.J.