SAN DIEGO Colin Kaepernick looks ready for his first full season as a starter.
Mike McCoy's San Diego Chargers look as if they could use a few more weeks of training camp.
Kaepernick threw a touchdown pass to cap his only drive, and the 49ers roughed up the Chargers 41-6 in the preseason finale for both teams Thursday night.
Kaepernick faked an inside handoff and then threw a short sidearm pass to Quinton Patton, who deked rookie free agent Marcus Cromartie and completed a 43-yard scoring play.
Coach Jim Harbaugh started the first-team offense of the 49ers (3-1), while McCoy sat his first-team defense.
The Chargers (1-3) had a bad night.
Backup quarterback Charlie Whitehurst was sacked four times in the first half, and third-stringer Brad Sorensen threw two interceptions in the second half.
San Francisco linebacker Cam Johnson sacked Whitehurst twice and blocked a punt by Mike Scifres and recovered it in the end zone for a touchdown late in the third quarter.
The defending NFC champion 49ers open at home against Green Bay a week from Sunday.
The Chargers, who have missed the playoffs for three straight seasons, open at home against Houston a week from Monday.
Chargers wide receiver Robert Meachem, who has a guaranteed $5 million salary, had four catches before sustaining a concussion.
He has been a forgotten man since dropping a potential touchdown pass in a 7-6 loss at Cleveland last season.
San Francisco free-agent pickup Lavelle Hawkins had a spectacular 45-yard touchdown play in the fourth quarter.
A short pass from B.J. Daniels bounced off Hawkins' hands and into the air, but the wide receiver grabbed it before being hit by Jahleel Addae. The rookie safety didn't wrap up, and Hawkins swept to the left and finished the scoring run for a 34-6 49ers lead.
Kaepernick is entering his first full season as a starter after making 10 starts last year and leading the 49ers to the Super Bowl, in which they lost to the Baltimore Ravens.
With Harbaugh playing his starters, the mismatch paid off as the 49ers moved 77 yards in seven plays for the score.
Kaepernick completed 3 of 4 passes for 64 yards for a rating of 156.2. He had no carries.
Colt McCoy, selected as the backup last weekend after he restructured his contract, replaced Kaepernick and played into the third quarter.
McCoy also threw a touchdown pass, a 5-yarder to Anthony Dixon in the second quarter.
McCoy completed 8 of 15 passes for 56 yards.
Daniels also threw a 15-yard touchdown pass to rookie Chuck Jacobs and had a 36-yard run on that drive.
Quarterback Seneca Wallace, who was signed last week by the 49ers, did not travel with the team to San Diego, signaling he will be released.
The 49ers said Wallace, a nine-year veteran, chose not to make the trip for "personal reasons."
Wallace, 33, had been scheduled to make an entrance late in the game. He did not play last season and was cut by the Saints earlier this month.
Whitehurst was 9 of 12 for 86 yards, with one interception.
Chargers rookie linebacker Manti Te'o was back in his walking boot as he watched the game from the sideline in a sweatsuit.
Te'o sprained his right foot in the exhibition opener against Seattle on Aug. 8. He was out of the boot Tuesday, although he hasn't been cleared to practice.
The Bee's Matthew Barrows contributed to this story.