SANTA CLARA The 49ers, who entered Sunday's game in Seattle with only one player, running back LaMichael James, on their injury report, emerged from it with 10 injured players, including quarterback Colin Kaepernick and their entire starting defensive line.
Kaepernick is listed with a foot injury but practiced Wednesday. So did left guard Mike Iupati, who has a shoulder injury. Iupati had surgery on his shoulder in the offseason and didn't participate in the 49ers' organized team activities in May and June.
Defensive ends Ray McDonald and Justin Smith didn't practice. Smith is listed with a shoulder injury, while McDonald has two injured ankles. A right ankle sprain late in the game sent McDonald to the locker room and threatens to keep him out of Sunday's game against the Colts. Starting nose tackle Ian Williams was lost for the season when he suffered a broken ankle in the first quarter.
Tight end Vernon Davis, who strained his hamstring in the fourth quarter, and James, who still is dealing with a knee injury suffered in the preseason finale, also didn't practice.
Starting defensive players NaVorro Bowman (wrist), Eric Reid (concussion) and Aldon Smith (back) were limited in practice.
Reid practiced in a blue, noncontact uniform. The rookie safety has not shown any symptoms since his concussion against the Seahawks but still must pass the league's post-concussion protocol before being cleared to play against the Colts.
Aldon Smith briefly left Sunday's game and was replaced by rookie Corey Lemonier at outside linebacker. Smith finished the game and had two sacks. He has 3 1/2 this season, tying him for third in the league.
Luck's encounter Colts quarterback Andrew Luck was the first person to give 49ers coach Jim Harbaugh a scouting report on Kaepernick. Luck was Harbaugh's starting quarterback at Stanford when he attended the Manning Passing Academy alongside Kaepernick and other top college football passers in 2010.
"When Andrew got back from the academy, just asked him what quarterbacks stood out to him, who was good, and I asked him who he got along with," Harbaugh said Wednesday. "He lit up talking about Colin. It was the first name out of his mouth."
Luck was fuzzier on the details during a conference call.
"I must have said something because I remember people talking about that as a story when he got drafted," Luck said. "But I don't remember a specific conversation at that point."
Marecic's role Harbaugh said recent acquisition Owen Marecic would back up Bruce Miller at fullback and would, initially at least, have a backup role on special teams. That may be a hint that Marecic will not be among the 46 players in uniform against Indianapolis.
Asked why the 49ers didn't sign a nose tackle to replace Williams on the roster, Harbaugh said the team was confident Tony Jerod-Eddie could fill the backup role behind Glenn Dorsey. To this point, Jerod-Eddie mostly has played defensive end in the team's 3-4 scheme.
"We feel like it's his time to step up," Harbaugh said of Jerod-Eddie. "He's the next man up and deserves the opportunity."