Drew Stanton threw two touchdown passes to rookie John Brown and the Arizona Cardinals remained unbeaten with a 23-14 win over the San Francisco 49ers on Sunday.

San Francisco 49ers tight end Vernon Davis is out for Sunday's game against the Arizona Cardinals.

Despite a 10-win season, the Arizona Cardinals did not make the playoffs in 2013, in part because of a loss to the San Francisco 49ers in their regular season finale.

San Francisco 49ers tight end Vernon Davis is questionable for Sunday's game against the Arizona Cardinals.

Despite a 10-win season, the Arizona Cardinals did not make the playoffs in 2013, in part because of a loss to the San Francisco 49ers in their regular season finale.

All it took was a new stadium for the Chicago Bears to end their near 30-year hex in San Francisco.

It may be a new stadium, but the San Francisco 49ers are hoping the results don't change against the Chicago Bears.

Santa Clara, CA (Sports Network) - The San Francisco 49ers waived running back LaMichael James on Monday.

San Francisco picked off Tony Romo three straight times, and the 49ers opened the 2014 season with a convincing 28-17 victory over the Dallas Cowboys.

The San Francisco 49ers removed guard Alex Boone from the exempt list in time for the recent holdout to play in Sunday's season opener at Dallas.

San Francisco 49ers wide receiver Michael Crabtree is listed as questionable for Sunday's season opener against the Dallas Cowboys.

As talented as the San Francisco 49ers can be on offense, it has been their defense that has led the charge to three straight NFC Championship Game appearances.

San Francisco 49ers nose tackle Glenn Dorsey will be sidelined for at least the first half of the 2014 season after being placed on injured reserve as the team's designated to return player.

San Francisco 49ers guard Alex Boone finally reported to the team on Monday after staging a prolonged holdout over dissatisfaction over his contract.

San Francisco 49ers defensive end Ray McDonald has been arrested early Sunday morning on felony charges of domestic violence.

The San Francisco 49ers pared down their roster to the NFL-mandated limit of 53 players by releasing a host of veteran special-teams players.

San Francisco 49ers linebacker Aldon Smith was suspended nine games without pay on Friday for violating the NFL's Policy and Program for Substance of Abuse and the league's Personal Conduct Policy.

Josh Johnson threw three touchdown passes to lead the San Francisco 49ers to a 40-13 victory over the Houston Texans in the preseason finale for both teams.

The Houston Texans will close out the preseason against the San Francisco 49ers Thursday at NRG Stadium.

For one, there is the fact that the Niners are in perhaps the toughest division in football, one that contains the reigning Super Bowl winners in the Seattle Seahawks.

All-Pro linebacker NaVorro Bowman was officially placed on the reserve/physically unable to perform list by the San Francisco 49ers as the team pared down its active roster to 75 players on Monday.

Colin Kaepernick was 6-of-12 for 59 yards and the San Francisco 49ers defeated the San Diego Chargers, 21-7, in preseason action on Sunday afternoon.

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