Arizona Cardinals quarterback Carson Palmer, who suffered a concussion Sunday against the Los Angeles Rams, won’t make the trip to Santa Clara for Thursday’s game against the 49ers, coach Bruce Arians told Phoenix-area reporters Wednesday.
Drew Stanton will replace Palmer in his first start since 2014. Stanton faced the 49ers early that season, a 23-14 Cardinals win in Arizona in which he threw for 244 yards and two touchdowns. On Sunday, Stanton completed 4 of 11 attempts for 37 yards with two interceptions.
“He’s done it,” Arians said of Stanton. “He was 5-3 as our starter when Carson was hurt (in 2014) and I thought he played extremely well. We won’t change anything we do. He’s extremely knowledgeable in the offense and I feel very comfortable with him in there.”
Earlier in the week, the Cardinals placed running back Chris Johnson on injured reserve because of a groin injury. David Johnson has been their starting running back this season and is seeking his first 100-yard rushing effort of 2016. The 49ers have given up at least 100 yards to a rusher in the last three games.
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Meanwhile, rookie DeForest Buckner, who has logged more snaps than any 49ers defensive lineman this season, is out because of a foot injury. Arik Armstead or Mike Purcell could start at defensive end for Buckner. Cornerback Jimmie Ward, who is coming back from a quadriceps strain, also is sidelined, and rookie Rashard Robinson likely will start in Ward’s place for the second consecutive game.
Defensive lineman Glenn Dorsey (knee), wide receiver Jeremy Kerley (ankle) and tight end Vance McDonald (hip) are questionable. All three were limited in Wednesday’s practice.