- Opponent: at Arizona Cardinals
- Time: 1:25 p.m.
- Line: Cardinals by 13 1/2
- Records: 49ers 1-7, Saints 3-4-1
- TV/radio: Ch. 40 (Chris Myers, Ronde Barber), 680, 1320
Three things to watch
MORE PHYSICAL PLAY BY DuJUAN HARRIS
Whether Carlos Hyde returns Sunday from a shoulder injury he suffered Oct. 16 against the Buffalo Bills, DuJuan Harris should continue to get meaningful playing time at running back. He has been excellent as a pass catcher and, belying his 5-foot-7 frame, refused to go down easily on first contact. The 49ers need more effort like that if they are to break their seven-game losing streak.
IT’S A GOOD TIME FOR A DEFENSIVE TURNOVER
Early in his career, Tramaine Brock was an interception machine. But the starting cornerback hasn’t had an interception since Oct. 22, 2015. Snatching his first interception this season – or any kind of takeaway – is critical for a 49ers defense that doesn’t seem to have much fire or passion and could use some momentum.
WILL KAEPERNICK CONTINUE UPSWING?
The lowest moment of Colin Kaepernick’s career came at Arizona last year when he recorded no passing touchdowns and threw four interceptions, two of which were returned for scores. Since returning to the starting role Oct. 16, Kaepernick has been lifting himself off the mat and is coming off his best performance in a while. The question is whether he can continue his growth against the Cardinals’ swarming defense.
- Out: S Tyrann Mathieu (shoulder), CB Tharold Simon (ankle)
- Questionable: LB Alex Okafor (calf)
- Out: LB Aaron Lynch (ankle)
- Questionable: RB Carlos Hyde (shoulder), CB Rashard Robinson (knee), WR Torrey Smith (back)
vs. Los Angeles
vs. Tampa Bay
vs. New Orleans
vs. New England
vs. N.Y. Jets
at Los Angeles