A multivehicle crash blocked lanes on westbound Highway 50 Sunday afternoon, the California Highway Patrol said.
One vehicle overturned, but there were no injuries, said CHP spokesman Michael Bradley.
Bradley said all westbound lanes between 51st and 65th streets were closed for a few hours.
One driver was in custody on suspicion of driving under the influence of drugs or alcohol, Bradley said. There is no indication whether that person was at fault in the crash, he added.