A statistical look at the 49ers’ 45-16 loss to the Buffalo Bills on Sunday in Orchard Park, N.Y.:
1: Touchdown pass for 49ers’ quarterback Colin Kaepernick in his first start of the season. It was his first TD pass since Oct. 18, 2015.
3: Points scored by the 49ers in the second half. They trailed just 17-13 at the break.
3: Rushing touchdowns for Buffalo Bills running back LeSean McCoy.
4: Consecutive wins for the Bills, the first time Buffalo has done that since 2008.
5: Losses in a row for the 49ers, who haven’t won since shutting out the Los Angeles Rams in the season opener.
5: Consecutive games in which the 49ers allowed an opposing running back to amass 100 or more yards. McCoy had 140 on Sunday.
6: Penalties on the 49ers, costing the team 61 yards.
21: Fourth-quarter points for the Bills, turning a one-score game into a rout. The 49ers had just a field goal in the final 15 minutes.
23.1: Third-down percentage for the 49ers (3 for 13). The Bills were 8 for 13 (61.5 percent)
76: Receiving yards for the 49ers’ Torrey Smith, a game high.
77.8: Passer rating for Kaepernick.
100: Red-zone percentage for the Bills, who were 4 for 4. The 49ers were 0 for 2.
100: Kicking percentage for the 49ers’ Phil Dawson. He was 3 for 3 on field goals and made his only PAT for 10 points.
185: Points allowed by the 49ers this season, the highest total in the NFL.
187: Passing yards for Kaepernick.
312: Rushing yards allowed by the 49ers, second most in team history. They gave up 324 to the Los Angeles Rams in 1958.
Compiled by Noel Harris