SANTA CLARA -- The 49ers began the half like a lion and ended it like a lamb.
Sharp throwing by Colin Kaepernick, including a 17-yard touchdown to Shaun Draughn, gave the 49ers a 14-0 lead. But an encouraging first quarter turned into a rough second quarter that allowed the Buccaneers to take the lead, 17-14.
Kaepernick did not throw an incompletion on his initial drive, hitting tight end Vance McDonald for 24 yards and Torrey Smith for 17. The latter set up Mike Davis' four-yard touchdown run, the first of his career.
The 49ers have used several inside linebacker combinations this season. Today's -- Gerald Hodges and Nick Bellore -- paid dividends at the end of the first quarter when cornerback Tramaine Brock deflected a Jameis Winston pass and Hodges returned the ball to the Tampa Bay 17-yard line.
On the next play, Kaepernick scrambled out of the pocket and found Draughn in the corner of the end zone. The play was Draughn's first of the game. Davis and DuJuan Harris were the only running backs to get carries in the first half.
The Buccaneers scored in the second quarter on a four-yard pass from Winston to receiver Mike Evans. The touchdown pass set up by a screen pass to Antone Smith that gained 30 yards, plus additional yardage when safety Antoine Bethea was flagged for a horse-collar tackle on Smith.
Kaepernick's first interception of the season gave the Buccaneers the ball at their own 27-yard line and led to a 45-yard run by Jacquizz Rodgers, which set up a Buccaneers field goal. Rodgers had 110 yards at the half, making the sixth straight rusher to hit the 100-yard mark against the 49ers and their league-worst run defense. It was the second straight game an opponent had gone over 100 yards by halftime.
The Buccaneers have 307 yards of offense at the half; Their season-high is 472 yards against the Rams in Week 3.
Kaepernick is 9-16 for 93 yards and a 68 passer rating. He leads the team with 38 rushing yards.