- Opponent: at Seattle Seahawks
- Time: 1:05 p.m.
- Line: Seahawks by 9
- Records: 49ers 1-1, Seahawks 1-1
- TV/radio: Ch. 40 (Kevin Burkhardt, John Lynch), 810, 1320
Three things to watch
The 49ers are using safety Eric Reid all over the field this year, including as a blitzer and as a nickel back. On Sunday, he likely will be matched up a lot against Seahawks tight end Jimmy Graham, especially with the 49ers’ top linebacker in coverage, Ray-Ray Armstrong, on injured reserve.
TALE OF TWO VANCES
San Francisco fans got another look at the two Vance McDonalds vs. Carolina: The one capable of scoring from 75 yards and the one capable of dropping a deep pass at a critical point in the game. That fourth-quarter drop preceded a Blaine Gabbert interception that all but ended the 49ers’ comeback. The tight end is one of the 49ers’ two most explosive pass catchers, and they need him to be consistent to win in Seattle.
ROOKIE PURSUES WILSON
The 49ers have leaned on rookie DeForest Buckner more than any defensive lineman in the first two games. Buckner will be asked to disrupt Seattle quarterback Russell Wilson, but more importantly get him on the ground, something the 49ers failed to accomplish with Carolina’s Cam Newton in Week 2.
- Out: T Anthony Davis (concussion)
- Questionable: S Marcus Cromartie (ankle), S Jaquiski Tartt (knee)
- Doubtful: TE Nick Vannett (ankle), G Germain Ifedi (ankle), RB Thomas Rawls (shin)
- Questionable: RB C.J. Prosise (wrist), WR Tyler Lockett (knee)
vs. Los Angeles
Ch. 13, NFL
vs. Tampa Bay
vs. New Orleans
vs. New England
vs. N.Y. Jets
at Los Angeles