49ers pregame: Glenn Dorsey, Vance McDonald inactive vs. Cardinals

SANTA CLARA -- The 49ers will be without defensive lineman Glenn Dorsey and tight end Vance McDonald for tonight’s game against the Cardinals.

Dorsey, who is coming back from an ACL tear and who played in the last three games, was a late-week addition to the injury report with a knee issue. He practiced in full Monday and Tuesday but was limited on Wednesday. The 49ers listed him as questionable on their final report.

Dorsey went through a full workout before today’s game.

Earlier in the week, defensive coordinator Jim O’Neil said the 49ers were contemplating a bigger role for Dorsey, perhaps at nose tackle, a position that’s been manned by Mike Purcell early this season. The 49ers have the worst run defense in the NFL through four weeks, and they’ve allowed a 100-yard rusher in each of the last three games.

With rookie DeForest Buckner (foot) also out for this game, the 49ers’ defensive linemen will be Purcell, Quinton Dial, Arik Armstead, Ronald Blair, Tony Jerod-Eddie and Taylor Hart. Hart is in uniform for the first time this season.

Outside linebacker Aaron Lynch also will be active for the first time this year after serving a four-game suspension. Lynch took linebacker NaVorro Bowman’s roster spot. Bowman, who tore an Achilles tendon Sunday, went on injured reserve Thursday. Nick Bellore will start in his place against the Cardinals.

McDonald, meanwhile, injured the hip on a big hit from Seahawks safety Kam Chancellor in Week 3. He practiced on a limited basis this week and was listed as questionable for the game. For the second straight game, the 49ers’ active tight ends will be Garrett Celek, Blake Bell and Je’Ron Hamm. Hamm didn’t get into Sunday’s game against the Cowboys.

49ers inactives

QB Christian Ponder

DL Glenn Dorsey

TE Vance McDonald

OL John Theus

DL DeForest Buckner

CB Jimmie Ward

WR Keshawn Martin

Cardinals inactives

QB Carson Palmer

G Cole Toner

DT Olsen Pierre

TE Darren Fells

DL Robert Nkemdiche

DT Ed Stinson

DT Josh Mauro.

This story was originally published October 6, 2016 at 4:07 PM.