Week 1, Sept. 14 vs. Minnesota, 7:20 p.m., ESPN
A 49ers team that wasn't allowed to play a non-holiday prime time game last year at Levi's Stadium will kick off the season on Monday, Sept. 14. Fun fact: The 49ers and Vikings are currently tied for most players arrested since 2012. Both have 11.
Week 2, Sept. 20 at Pittsburgh, 10 a.m., FOX
The last time the 49ers were in the Steel City, Pittsburgh safety Troy Polamalu injured Vernon Davis early on with a nasty submarine shot to the tight end's ankles. (I'll end the suspense: The 49ers lost). Polamalu won't be an issue this time. He announced his retirement recently, ending a 12-year career. The 49ers also might avoid Steelers running back Le’Veon Bell, who ranked second in the NFL in yards from scrimmage in 2014, and who is expected to serve a three-game suspension to start the season. One bummer for the 49ers: Pittsburgh opens the season on a Thursday, which means they have three extra days to prepare.
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Week 3, Sept. 27 at Arizona, 1:05 p.m., FOX
This battle promises to start early with a few Twitter skirmishes between Darnell Dockett and his ex teammates. Dockett's opponent, however, could be a familiar one. After Dockett headed to San Francisco, guard Mike Iupati went in the opposite direction
Week 4, Oct. 4 vs. Green Bay, 1:25, FOX
Colin Kaepernick has yet to lose to his boyhood-favorite team from his home state. Meanwhile, Aaron Rogers hasn't beaten his boyhood-favorite team from his home state since 2010.
Week 5, Oct. 11 at Giants, 5:30 p.m., NBC
The 49ers visit the Meadowlands for the second straight season. Last year they held eventual offensive rookie of the year Odell Beckham Jr. to just 93 receiving yards and no touchdowns. Considering he averaged 119 yards in his 11 starts, that's not too shabby.
Week 6, Oct. 18 vs. Baltimore, 1:25 p.m., CBS
Like some figure from a Greek tragedy arriving to avenge his brother's death, John Harbaugh gets to strike a blow at the team that mutually parted his little bro. Fun fact: The Ravens were one of six teams Jim Harbaugh did not defeat while with the 49ers. The others: the Broncos, Vikings, Raiders, Chargers and Colts.
Week 7, Oct. 22 (Thurs) vs. Seattle, 5:30 p.m., CBS, NFLN
Worst game of 2014 for the 49ers? It needs to be multiple choice: A) Week 13 at home vs. Seattle; B) Week 14 at Oakland; C) Week 2 at home vs. Chicago; D) Week 7 at Denver. I'll also accept: E) All of the above.
Week 8, Nov. 1 at St. Louis, 10 a.m., FOX
Could this be the last time the 49ers head to the 'Gateway to the West' to play their division rivals? The Rams are believed to be the frontrunners to play in Los Angeles starting in 2016, which would add a jolt to the rivalry. (See: Giants-Dodgers; Sharks-Kings).
Week 9, Nov. 8 vs. Atlanta, 1:05. p.m, FOX
The last time the 49ers saw the Falcons, NaVorro Bowman was sprinting downfield for a game-sealing 89-yard touchdown return in what turned out to be the perfect farewell to Candlestick Park. A goal this season: Getting more comfortable at Levi's Stadium, where the 49ers were a ho-hum 4-4 in Year 1.
Week 10, Nov. 15 BYE
Week 11, Nov. 22 at Seattle, 1:25 p.m., FOX
Forecast calls for light rain, fog and periods of heavy decibels.
Week 12, Nov. 29 vs. Arizona, 1:25 p.m., FOX
Yes, the 49ers have had a hard time winning in Seattle. A less-reported phenomenon: The Cardinals can't win on the road against the 49ers. Their last victory in the Bay Area was in September 2008.
Week 13, Dec. 6 at Chicago, 10 a.m., FOX
The 49ers visit two old friends, former defensive coordinator Vic Fangio and defensive backs coach Ed Donatell. That duo received the most credit for a 49ers defense that was a Top 5 unit in each of the last four years, but each man was passed over for promotion. Is a deep dish of revenge in store for the 49ers? Eh, probably not this year. The Chicago defense will take time to rebuild.
Week 14, Dec. 13 at Cleveland, 10 a.m., FOX
Imagine how juicy this game would have been if Jim Harbaugh had landed here after the 2013 season? ... The last time the 49ers visited the Browns, Chris Weinke was San Francisco's starting quarterback. (I'll end the suspense: The 49ers lost.) ... The 49ers could be staying in Youngstown, Ohio the week before this game.
Week 15, Dec. 20 vs. Cincinnati, 5:30 p.m., NBC
The last time the Bengals visited, a "Fire Mike Nolan" banner was supposed to fly over the stadium. Nolan and the 49ers won the game and the head coach kept his job ... until he was fired midway through the following season.
Week 16, Dec. 27 at Detroit, 10 a.m., FOX
The 49ers head to Detroit for the first time since the infamous "handshake" game. In case you haven't heard, Jim Tomsula is a bit more genial than the guy he replaced and is unlikely to be involved in any after-game dust-ups. The Lions have lost nine straight games to San Francisco and haven't beaten the 49ers since 1995.
Week 17, Jan. 3 vs. St. Louis, 1:25 p.m., FOX
Nick Foles -- assuming he's still healthy at this point in the season -- will be the fifth Rams starting quarterback to face the 49ers since 2011.
In addition, the 49ers’ preseason dates are known. They will play:
* Aug 15: at Houston, 5 p.m.
* Aug. 23: vs. Dallas, 5 p.m.
* Aug. 29: at Denver, 6 p.m.
* Sept. 3: vs. San Diego, 7 p.m.
Read Matt Barrows’ blogs and archives at sacbee.com/sf49ers.