Offense: Colin Kaepernick, who seemed to be playing the safest and smartest football in more than a year, throws a career-high four interceptions. The first two, for Cardinals touchdowns, put San Francisco in a quick hole they are incapable of escaping. Meanwhile, the team's offensive-line woes continue. Grade: F
Defense: For the second straight week, the opposing offense can go into cruise control in the second half because of the lopsided score. Still, the 49ers allow Carson Palmer to gobble up yards in big chunks. And a week after giving up 195 yards to receiver Antonio Brown, they allow Arizona's Larry Fitzgerald 134 receiving yards and two touchdowns. Grade: D-
Special teams: Jarryd Hayne has an aggressive punt return for 37 yards that sets up the 49ers' only score of the game. But it also begs the question why DeAndrew White, and not Hayne, was returning kicks. White averaged 23.8 yards on his four returns and fumbled one that was recovered by teammate. Grade: C+
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Overall: The 49ers look as bad as they ever did during their most feeble outings under Dennis Erickson, Mike Nolan and Mike Singletary. They have given up 43 or more points in two straight weeks and have to face the 2-0 Packers and quarterback Aaron Rodgers next week. After that is their longst road trip of the year to face the Giants. Grade: F