A Seahawks offense that managed only 15 points total in its first two games seems to have found a cure-all in the 49ers defense.

Seattle is up 24-3 with two touchdowns from running back Christine Michael, who replaced injured Thomas Rawls for the game. Last year Rawls rolled up 209 rushing yards in a game against San Francisco. Michael already has 12 carries for 82 yards.

The 49ers also have been vulnerable through the air with Doug Baldwin grabbing passes of 34 and 59 yards. The 59-yard pass play -- against the 49ers' top cornerback, Tramaine Brock -- set up an 18-yard touchdown pass from Russell Wilson to tight end Jimmy Graham. Baldwin has three catches for 105 yards.

The Seahawks offense has 317 yards; the 49ers have 102. Seattle held the ball for 18:27 to 11:33 for the 49ers.

San Francisco’s three points came after NaVorro Bowman forced a Graham fumble and fellow inside linebacker Gerald Hodges recovered the ball at Seattle’s 30-yard line.

Meanwhile, the 49ers lost one player, cornerback Jimmie Ward, to a quadriceps injury when he went down, without contact, while on kickoff coverage. The 49ers immediately ruled Ward out for the rest of the game, signaling that the injury is serious. Keith Reaser took over for Ward at cornerback.

Tight end Vance McDonald left the game earlier in the game with a hip injury and did not return.

The 49ers have lost Mario Manningham (knee), Ian Williams (ankle), Bowman (knee) and Glenn Dorsey (knee) for the season in recent in Seattle.